ParkinsonCanadaV1, Main, Exploration, bibRecord, 002A94

Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice

Identifieur interne : 002A94 ( Main/Exploration ); précédent : 002A93; suivant : 002A95

Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice

Auteurs : J. Lewis [États-Unis] ; G. Bench [États-Unis] ; O. Myers [États-Unis] ; B. Tinner [Canada] ; W. Staines [Canada] ; E. Barr [États-Unis] ; K. K. Divine [États-Unis] ; W. Barrington [États-Unis] ; J. Karlsson [États-Unis]

Source :

Neurotoxicology : (Park Forest South) [ 0161-813X ] ; 2005.

RBID : Pascal:05-0080849

Descripteurs français

Pascal (Inist)
- Nerf trijumeau, Parkinson maladie, Captation, Clairance, Inhalation, Manganèse chlorure, Animal, Rat, Souris, Nez, Toxicité, Système nerveux pathologie, Métal, Transport.
Wicri :
- topic : Métal.

English descriptors

KwdEn :
- Animal, Clearance, Inhalation, Manganese chloride, Metal, Mouse, Nervous system diseases, Nose, Parkinson disease, Rat, Toxicity, Transport, Trigeminal nerve, Uptake.

Abstract

Inhaled manganese (Mn) can enter the olfactory bulbs via the olfactory epithelium, and can then be further transported trans-synaptically to deeper brain structures. In addition to olfactory neurons, the nasal cavity is innervated by the maxillary division of the trigeminal nerve that projects to the spinal trigeminal nucleus. Direct uptake and transport of inhaled metal particles in the trigeminal system has not been investigated previously. We studied the uptake, deposition, and clearance of soluble Mn in the trigeminal system following nose-only inhalation of environmentally relevant concentrations. Rats and mice were exposed for 10-days (6 h/day, 5 days/week) to air or MnCl₂ aerosols containing 2.3 ± 1.3 mg/m³ Mn with mass median aerodynamic diameter (MMAD) of 3.1 ± 1.4 μm for rats and 2.0 ± 0.09 mg/m³ Mn MnCl₂ with MMAD of 1.98 ± 0.12 μm for mice. Mn concentrations in the trigeminal ganglia and spinal trigeminal nucleus were measured 2 h (0-day), 7-, 14-, or 30-days post-exposure using proton induced X-ray emission (PIXE). Manganese-exposed rats and mice showed statistically elevated levels of Mn in trigeminal ganglia 0-, 7- and 14-days after the 10-days exposure period when compared to control animals. The Mn concentration gradually decreased over time with a clearance rate (t_1/2) of 7-8-days. Rats and mice were similar in both average accumulated Mn levels in trigeminal ganglia and in rates of clearance. We also found a small but significant elevation of Mn in the spinal trigeminal nucleus of mice 7-days post-exposure and in rats 0- and 7-days post-exposure. Our data demonstrate that the trigeminal nerve can serve as a pathway for entry of inhaled Mn to the brain in rodents following nose-only exposure and raise the question of whether entry of toxicants via this pathway may contribute to development of neurodegenerative diseases.

Affiliations:

Canada, États-Unis

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Le document en format XML

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<series><title level="j" type="main">Neurotoxicology : (Park Forest South)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Clearance</term>
<term>Inhalation</term>
<term>Manganese chloride</term>
<term>Metal</term>
<term>Mouse</term>
<term>Nervous system diseases</term>
<term>Nose</term>
<term>Parkinson disease</term>
<term>Rat</term>
<term>Toxicity</term>
<term>Transport</term>
<term>Trigeminal nerve</term>
<term>Uptake</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Nerf trijumeau</term>
<term>Parkinson maladie</term>
<term>Captation</term>
<term>Clairance</term>
<term>Inhalation</term>
<term>Manganèse chlorure</term>
<term>Animal</term>
<term>Rat</term>
<term>Souris</term>
<term>Nez</term>
<term>Toxicité</term>
<term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">Inhaled manganese (Mn) can enter the olfactory bulbs via the olfactory epithelium, and can then be further transported trans-synaptically to deeper brain structures. In addition to olfactory neurons, the nasal cavity is innervated by the maxillary division of the trigeminal nerve that projects to the spinal trigeminal nucleus. Direct uptake and transport of inhaled metal particles in the trigeminal system has not been investigated previously. We studied the uptake, deposition, and clearance of soluble Mn in the trigeminal system following nose-only inhalation of environmentally relevant concentrations. Rats and mice were exposed for 10-days (6 h/day, 5 days/week) to air or MnCl<sub>2</sub>
 aerosols containing 2.3 ± 1.3 mg/m<sup>3</sup>
 Mn with mass median aerodynamic diameter (MMAD) of 3.1 ± 1.4 μm for rats and 2.0 ± 0.09 mg/m<sup>3</sup>
 Mn MnCl<sub>2</sub>
 with MMAD of 1.98 ± 0.12 μm for mice. Mn concentrations in the trigeminal ganglia and spinal trigeminal nucleus were measured 2 h (0-day), 7-, 14-, or 30-days post-exposure using proton induced X-ray emission (PIXE). Manganese-exposed rats and mice showed statistically elevated levels of Mn in trigeminal ganglia 0-, 7- and 14-days after the 10-days exposure period when compared to control animals. The Mn concentration gradually decreased over time with a clearance rate (t<sub>1/2</sub>
) of 7-8-days. Rats and mice were similar in both average accumulated Mn levels in trigeminal ganglia and in rates of clearance. We also found a small but significant elevation of Mn in the spinal trigeminal nucleus of mice 7-days post-exposure and in rats 0- and 7-days post-exposure. Our data demonstrate that the trigeminal nerve can serve as a pathway for entry of inhaled Mn to the brain in rodents following nose-only exposure and raise the question of whether entry of toxicants via this pathway may contribute to development of neurodegenerative diseases.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
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<tree><country name="États-Unis"><noRegion><name sortKey="Lewis, J" sort="Lewis, J" uniqKey="Lewis J" first="J." last="Lewis">J. Lewis</name>
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<name sortKey="Divine, K K" sort="Divine, K K" uniqKey="Divine K" first="K. K." last="Divine">K. K. Divine</name>
<name sortKey="Karlsson, J" sort="Karlsson, J" uniqKey="Karlsson J" first="J." last="Karlsson">J. Karlsson</name>
<name sortKey="Myers, O" sort="Myers, O" uniqKey="Myers O" first="O." last="Myers">O. Myers</name>
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<name sortKey="Staines, W" sort="Staines, W" uniqKey="Staines W" first="W." last="Staines">W. Staines</name>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice

Trigeminal uptake and clearance of inhaled manganese chloride in rats and mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri